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IGF-1 DES 1mg


Buy 1mg of IGF-1 DES

The product labeled as “IGF-1 DES 1mg” is a single, non-glycosylated polypeptide that belongs to the IGF-1 family of peptides. In vitro studies have shown that DES (1-3) IGF is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells when equal doses are used. IGF-1 DES is a cleaved form of IGF-1 that contains amino acids 4-70. IGF-1 and IGF-1 DES play important roles in the growth and development of growth hormone by mediating many of the growth-promoting effects. Despite being shorter than IGF-1, IGF-1 DES has been shown to pack an equal amount of protein with physiological altering properties. Studies have demonstrated that growth hormone does not directly stimulate the incorporation of sulfate into cartilage.

Des(1-3)IGF-1, on the other hand, is a naturally occurring protein that serves as a truncated analogue of IGF-1. It lacks the first three amino acids at the N-terminus of IGF-1, resulting in reduced binding to insulin-like growth factor-binding proteins and enhanced potency of around 10-fold in vivo relative to IGF-1. The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.