Sermorelin , also known as GRF 1-29, is a GHRH that stimulates the production and release of Growth Hormone. Sermorelin Acetate affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity. Compared to human Growth Hormone (hGH), Sermorelin Acetate is a growth hormone secretagogue. Which means that it stimulates the pituitary gland to produce and secrete growth hormone. Buy sermorelin
29 Amino Acids
The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure This fragment became known as GRF (1-29).Due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance.
This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment. This successful modification prompted the further creation of analogues with additional amino acid substitutions.
In 2005, the first specific mention of tetrasubstitued GRF (1-29) appeared in a study that used it as one of the GRF (1-29) analogue peptide structures studied.
In 2008, a researcher known as DatBtrue created the term modified GRF (1-29) in place of tetrasubstitued GRF (1-29) in his public articles. Continued use of the term on public and private forums has popularized and standardized the nomenclature.
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